Industry head-to-head trials favour sponsor

Clinical trials in head injury.

Traumatic brain injury (TBI) remains a major public health problem globally. In the United States the incidence of closed head injuries admitted to hospitals is conservatively estimated to be 200 per 100,000 population, and the incidence of penetrating head injury is estimated to be 12 per 100,000, the highest of any developed country in the world. This yields an approximate number of 500,000 n...

Treatment Comparison in Rheumatoid Arthritis: Head-to-Head Trials and Innovative Study Designs

Over the last decades, the increasing knowledge in the area of rheumatoid arthritis has progressively expanded the arsenal of available drugs, especially with the introduction of novel targeted therapies such as biological disease modifying antirheumatic drugs (DMARDs). In this situation, rheumatologists are offered a wide range of treatment options, but on the other side the need for compariso...

Galanin modulates the neural niche to favour perineural invasion in head and neck cancer

Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately, there is no targeted treatment for PNI since the molecular mechanisms are largely unknown. PNI is an active process, suggesting that cancer cells communicate with nerves. However, nerve-tumour crosstalk is understudied due to the lack of in vivo models to investigate the mechanisms. Here we developed ...

Characteristics of NIH- and industry-sponsored head and neck cancer clinical trials.

OBJECTIVES/HYPOTHESIS Compare U.S. clinical trials sponsored by the National Institutes of Health (NIH) and industry, especially with regard to trial design, interventions studied, and results reporting rates. STUDY DESIGN U.S. head and neck cancer clinical trials. METHODS We used information from ClinicalTrials.gov to compare NIH- and industry-sponsored head and neck cancer clinical trials...

Quality of randomised controlled trials in head injury. Trials in head injury are more complex than review suggests.